Not recommended — #30 of 31 Tweed ranks #30 of 31 fabrics for chafe resistance. It is a poor fabric for this. Ranked with a smooth-fibre bonus plus low weight and breathability. The top pick is Silk.
Tweed measures 50/100 for breathability, 14% moisture regain, 82/100 warmth, at 350 gsm. Chafe resistance rewards a smooth, light surface: Tweed has more surface texture at 350 gsm.